Apoptosis -| BclxL GZMB -| BclxL STAT3 -> BclxL NFKB -> BclxL BID -| BclxL DISC -| BclxL Apoptosis -| SMAD GPCR -> SMAD Apoptosis -| SPHK1 PDGFR -> SPHK1 Apoptosis -| Ceramide S1P -| Ceramide Fas -> Ceramide Apoptosis -| CTLA4 TCR -> CTLA4 Apoptosis -| TCR CTLA4 -| TCR Stimuli -> TCR Apoptosis -| PI3K RAS -> PI3K PDGFR -> PI3K Apoptosis -| Proliferation STAT3 -> Proliferation P27 -| Proliferation IL15 -> IL2RB Apoptosis -| IL2RB IL2RBT -> IL2RB IL2 -> IL2RB FasT -> sFas Apoptosis -| sFas IL15 -| SOCS Apoptosis -| SOCS JAK -> SOCS IL2 -| SOCS Apoptosis -| P2 P2 -> P2 IFNG -> P2 Stimuli2 -| P2 Apoptosis -| FYN TCR -> FYN IL2RB -> FYN Apoptosis -| RAS GRB2 -> RAS PLCG1 -> RAS GAP -| RAS Apoptosis -| S1P Ceramide -| S1P SPHK1 -> S1P Apoptosis -| TPL2 TNF -> TPL2 PI3K -> TPL2 TAX -> TPL2 BclxL -| BID MCL1 -| BID Apoptosis -| BID GZMB -> BID Caspase -> BID Apoptosis -| GPCR S1P -> GPCR Apoptosis -| FasT NFKB -> FasT Apoptosis -| Caspase GZMB -> Caspase BID -> Caspase DISC -> Caspase TRADD -> Caspase IAP -| Caspase Apoptosis -| MEK RAS -> MEK Apoptosis -| IFNGT NFAT -> IFNGT STAT3 -> IFNGT TBET -> IFNGT SOCS -| JAK IL2RA -> JAK Apoptosis -| JAK IFNG -> JAK RANTES -> JAK CD45 -| JAK IL2RB -> JAK Apoptosis -| A20 NFKB -> A20 FasT -> Fas Apoptosis -| Fas FasL -> Fas sFas -| Fas Apoptosis -| IL2RBT ERK -> IL2RBT TBET -> IL2RBT Apoptosis -| GZMB CREB -> GZMB IFNG -> GZMB TBET -> GZMB Apoptosis -| PLCG1 GRB2 -> PLCG1 PDGFR -> PLCG1 Apoptosis -> Apoptosis Caspase -> Apoptosis Apoptosis -| IL2 NFAT -> IL2 NFKB -> IL2 STAT3 -> IL2 TBET -| IL2 Apoptosis -| IL2RAT IL2 -> IL2RAT NFKB -> IL2RAT STAT3 -> IL2RAT Apoptosis -| ERK PI3K -> ERK MEK -> ERK IFNGT -> IFNG IL15 -> IFNG Apoptosis -| IFNG P2 -| IFNG Stimuli -> IFNG IL2 -> IFNG SMAD -| IFNG Apoptosis -| NFKB FLIP -> NFKB PI3K -> NFKB TPL2 -> NFKB IAP -> NFKB TRADD -> NFKB Apoptosis -| FLIP NFKB -> FLIP DISC -| FLIP CREB -> FLIP IFNG -> FLIP Apoptosis -| TRADD TNF -> TRADD A20 -| TRADD IAP -| TRADD Apoptosis -| Cytoskeleton_signaling FYN -> Cytoskeleton_signaling Apoptosis -| IAP NFKB -> IAP BID -| IAP Apoptosis -| NFAT PI3K -> NFAT Apoptosis -| TNF NFKB -> TNF Apoptosis -| CREB ERK -> CREB IFN -> CREB Apoptosis -| MCL1 PI3K -> MCL1 NFKB -> MCL1 STAT3 -> MCL1 IL2RB -> MCL1 Apoptosis -| RANTES NFKB -> RANTES LCK -> ZAP70 Apoptosis -| ZAP70 FYN -| ZAP70 Apoptosis -| GRB2 ZAP70 -> GRB2 IL2RB -> GRB2 FasT -> DISC Apoptosis -| DISC FLIP -| DISC Ceramide -> DISC IL2 -> DISC Fas -> DISC Apoptosis -| STAT3 JAK -> STAT3 Apoptosis -| P27 STAT3 -> P27 Apoptosis -| FasL ERK -> FasL NFAT -> FasL STAT3 -> FasL NFKB -> FasL IL2RA -| IL2RA Apoptosis -| IL2RA IL2 -> IL2RA IL2RAT -> IL2RA Apoptosis -| PDGFR PDGF -> PDGFR S1P -> PDGFR IL15 -| GAP Apoptosis -| GAP RAS -> GAP IL2 -| GAP GAP -> GAP PDGFR -> GAP Apoptosis -| LCK ZAP70 -| LCK CD45 -> LCK TCR -> LCK IL2RB -> LCK Apoptosis -| TBET JAK -> TBET TBET -> TBET $A20: (NFKB & !Apoptosis) $Apoptosis: (Apoptosis | Caspase) $BID: ((Caspase & !((BclxL | Apoptosis) | MCL1)) | (GZMB & !((BclxL | Apoptosis) | MCL1))) $BclxL: ((STAT3 & !(((GZMB | BID) | DISC) | Apoptosis)) | (NFKB & !(((GZMB | BID) | DISC) | Apoptosis))) $CREB: ((ERK & IFN) & !Apoptosis) $CTLA4: (TCR & !Apoptosis) $Caspase: ((((GZMB & BID) & !(Apoptosis | IAP)) | ((TRADD & BID) & !(Apoptosis | IAP))) | (DISC & !Apoptosis)) $Ceramide: (Fas & !(Apoptosis | S1P)) $Cytoskeleton_signaling: (FYN & !Apoptosis) $DISC: ((FasT & (((IL2 & Fas) | (Fas & !FLIP)) | Ceramide)) & !Apoptosis) $ERK: ((MEK & PI3K) & !Apoptosis) $FLIP: ((NFKB & !(DISC | Apoptosis)) | ((CREB & IFNG) & !(DISC | Apoptosis))) $FYN: ((TCR & !Apoptosis) | (IL2RB & !Apoptosis)) $Fas: ((FasT & FasL) & !(Apoptosis | sFas)) $FasL: ((((NFAT & !Apoptosis) | (NFKB & !Apoptosis)) | (STAT3 & !Apoptosis)) | (ERK & !Apoptosis)) $FasT: (NFKB & !Apoptosis) $GAP: (((PDGFR & GAP) & !((IL15 | Apoptosis) | IL2)) | (RAS & !((IL15 | Apoptosis) | IL2))) $GPCR: (S1P & !Apoptosis) $GRB2: ((ZAP70 & !Apoptosis) | (IL2RB & !Apoptosis)) $GZMB: ((TBET & !Apoptosis) | ((CREB & IFNG) & !Apoptosis)) $IAP: (NFKB & !(Apoptosis | BID)) $IFNG: ((((IL15 & IFNGT) & !((SMAD | Apoptosis) | P2)) | ((IL2 & IFNGT) & !((SMAD | Apoptosis) | P2))) | ((Stimuli & IFNGT) & !((SMAD | Apoptosis) | P2))) $IFNGT: (((NFAT & !Apoptosis) | (STAT3 & !Apoptosis)) | (TBET & !Apoptosis)) $IL2: (((NFAT & !(Apoptosis | TBET)) | (STAT3 & !(Apoptosis | TBET))) | (NFKB & !(Apoptosis | TBET))) $IL2RA: ((IL2 & IL2RAT) & !(IL2RA | Apoptosis)) $IL2RAT: ((IL2 & (NFKB | STAT3)) & !Apoptosis) $IL2RB: ((IL2RBT & (IL15 | IL2)) & !Apoptosis) $IL2RBT: ((ERK & TBET) & !Apoptosis) $JAK: ((((IL2RB & !((CD45 | SOCS) | Apoptosis)) | (IL2RA & !((CD45 | SOCS) | Apoptosis))) | (RANTES & !((CD45 | SOCS) | Apoptosis))) | (IFNG & !((CD45 | SOCS) | Apoptosis))) $LCK: (((TCR & !(Apoptosis | ZAP70)) | (CD45 & !Apoptosis)) | (IL2RB & !(Apoptosis | ZAP70))) $MCL1: ((IL2RB & ((PI3K & NFKB) & STAT3)) & !Apoptosis) $MEK: (RAS & !Apoptosis) $NFAT: (PI3K & !Apoptosis) $NFKB: ((((FLIP & (IAP & TRADD)) & !Apoptosis) | (PI3K & !Apoptosis)) | (TPL2 & !Apoptosis)) $P2: ((IFNG & !(Apoptosis | Stimuli2)) | (P2 & !(Apoptosis | Stimuli2))) $P27: (STAT3 & !Apoptosis) $PDGFR: ((PDGF & !Apoptosis) | (S1P & !Apoptosis)) $PI3K: ((PDGFR & !Apoptosis) | (RAS & !Apoptosis)) $PLCG1: ((GRB2 & !Apoptosis) | (PDGFR & !Apoptosis)) $Proliferation: (STAT3 & !(Apoptosis | P27)) $RANTES: (NFKB & !Apoptosis) $RAS: ((PLCG1 & !(GAP | Apoptosis)) | (GRB2 & !(GAP | Apoptosis))) $S1P: (SPHK1 & !(Apoptosis | Ceramide)) $SMAD: (GPCR & !Apoptosis) $SOCS: (JAK & !((IL15 | IL2) | Apoptosis)) $SPHK1: (PDGFR & !Apoptosis) $STAT3: (JAK & !Apoptosis) $TBET: ((JAK & !Apoptosis) | (TBET & !Apoptosis)) $TCR: (Stimuli & !(CTLA4 | Apoptosis)) $TNF: (NFKB & !Apoptosis) $TPL2: ((TAX & !Apoptosis) | ((PI3K & TNF) & !Apoptosis)) $TRADD: (TNF & !((A20 | Apoptosis) | IAP)) $ZAP70: (LCK & !(FYN | Apoptosis)) $sFas: (FasT & !Apoptosis)